
Autosomal dominant / Autosomal recessive (25% more severe) pattern of inheritance
Spherodial RBCs – which makes RBC less deformable and more vulnerable to splenic destruction.
Intrinsic defect in the RBC membrane.
Normally the biconcave shape of RBCs is function of RBC membrane proteins, specially spectrin and ankyrin, this proteins forms a meashlike network in intracellular face of membrane, this stabilize the membranes and is responsible of normal shape, strength and flexibility of RBC.
Mutations in this proteins leads to loosening of the membrane fragments as they are not stable, so the biconcave shape is disturbed, there by the surface area decreases, but the volume is not lost, so to maintain the ratio of surface area to volume, the RBC takes shape of sphere.
The spleen plays a major role in the destruction of spherocytes.
Cords of billroth -------splenic sinusoids.
The abnormal RBCs are sequestered and eventually destroyed by macrophages, which are plentiful in the splenic cords.

MORPHOLOGY
Microscopic - On smears, the RBCs lack the central zone of pallor because of their spheroidal shape. Increased erythropoiesis in the marrow is stimulated.
Peripheral smear shows – reticulocytosis.
Gross - Splenomegaly.
mbbs in Philippines
ReplyDeleteEvery year, almost 8000 foreign students take admission in Philippines Medical universities and out of which around 50% are Indian students. The standard of education in Philippines universities is well known around the world. Thousands of doctors from these medical universities are sent to various countries like USA and UK every year. There are around 2299 higher educational institutions and 40 medical colleges. The main benefits of pursuing MD degree from
Top Medical Colleges in Philippines :
EMILIO AGUINALDO COLLEGE OF MEDICINE
UNIVERSITY OF PERPETUAL HELP SYSTEM DALTA
LYCEUM NORTHWESTERN UNIVERSITY
DAVAO MEDICAL SCHOOL FOUNDATION
SOUTHWESTERN UNIVERSITY
Top Searched Topics on MBBS in Philippines
study mbbs in philippines
philippines medical colleges list
best medical colleges in philippines for indian students
philippines medical colleges
best medical colleges in philippines
mci approved medical colleges in philippines
for more information contact us : +91 90329 55688
MBBS in Philippines Wisdom Overseas is authorized India's Exclusive Partner of Southwestern University PHINMA, the Philippines established its strong trust in the minds of all the Indian medical aspirants and their parents. Under the excellent leadership of the founder Director Mr. Thummala Ravikanth, Wisdom meritoriously won the hearts of thousands of future doctors and was praised as the “Top Medical Career Growth Specialists" among Overseas Medical Education Consultants in India.
ReplyDeleteWhy Southwestern University PHINMA
5 years of total Duration
3D simulator technological teaching
Experienced and Expert Doctors as faculty
More than 40% of the US returned Doctors
SWU training Hospital within the campus
More than 6000 bedded capacity for Internship
Final year (4th year of MD) compulsory Internship approved by MCI (No need to do an internship in India)
Vital service centers and commercial spaces
Own Hostel accommodations for local and foreign students
Safe, Secure, and lavish environment for vibrant student experience
All sports grounds including Cricket, Volleyball, and others available for students