affecting some but not all glomeruli (focal involvement) and involving only segments of each affected glomerulus(segmental)
Primary ie idiopathic, or secondary GN due to HIV, heroin,IgA nephropathy
there is a higher incidence of hematuria and hypertension in persons with this lesion; their proteinuria is nonselective, and in general their response to corticosteroid therapy is poor
At least 50% of individuals with FSGS develop end-stage renal failure within 10 years of diagnosis
M/E
increased mesangial matrix, obliterated capillary lumens, and deposition of hyaline masses (hyalinosis) and lipid droplets
glomeruli are completely sclerosed (global sclerosis) in late cases
immunofluorescence microscopy often reveals nonspecific trapping of immunoglobulins, usually IgM, and complement
pronounced tubular atrophy and interstitial fibrosis. This advanced picture is difficult to differentiate from other forms of chronic glomerular disease
Focal segmental glomerulosclerosis, PAS stain. A, Low-power view showing segmental sclerosis in one of three glomeruli (at 3 o'clock). B, High-power view showing hyaline insudation and lipid (small vacuoles) in sclerotic area.
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mbbs in Philippines
ReplyDeleteEvery year, almost 8000 foreign students take admission in Philippines Medical universities and out of which around 50% are Indian students. The standard of education in Philippines universities is well known around the world. Thousands of doctors from these medical universities are sent to various countries like USA and UK every year. There are around 2299 higher educational institutions and 40 medical colleges. The main benefits of pursuing MD degree from
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UV GULLAS COLLEGE OF MEDICINE is one of Top Medical College in Philippines in Cebu city. International students have the oppertunity to study medicine in phillipines at affordable cost and world class University. The college has successful alumni who have achieved well in the fields of law, business, politics, academe, medicine, sports and other endeavors. At University of the Visayas, we prepare students for a global competition.
ReplyDeleteDirect MBBS Admissions Open: 2020-21
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ReplyDeleteWhy Southwestern University PHINMA
5 years of total Duration
3D simulator technological teaching
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SWU training Hospital within the campus
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