Deficiencies of Clotting factors
Onset - delayed after trauma
Deep bleeding
Into joints - Hemarthroses
Into deep tissues – Hematoma
large skin bleed – Ecchymoses
Common disease :
Hemophilia A
Hemophilia B
Vitamin K deficency
Von Willebrand Disease – Coagulation + platelet
Factor VIII Deficiency:
Classic hemophilia (hemophilia A)
X-linked disorder (affects 1ยบ males)
Most common - severe bleeding
Severity of disease -less than 1,2- 5, 5- 60%
Abnormal aPTT – Intrinsic path.
Diagnosis - factor VIII assay
Treatment - factor VIII concentrate
Cryoprecipitate
Recombinant factor VIII
Factor IX Deficiency:
Christmas disease (Hemophilia B)
X-linked recessive disorder
Indistinguishable from classic hemophilia (F VIII)
Requires evaluation of factor VIII and IX activity levels to diagnose
Treatment - factor IX concentrate
Cryoprecipitate if factor IX unavailable
Acquired coagulation disorder:
Vitamin K deficiency
- neonates - decreased intestinal
flora and dietary intake
- oral anticoagulants
- fat malabsorption syndromes
Required for factors II, VII, IX, X
Prolonged PT and aPTT
Laboratory findings in coagulation disorder:
Normal bleeding time & Platelet count
Prolonged prothrombin time (PT)
deficiencies of II, V, VII, X
Prolonged time (aPTT)
all factors except VII, XIII.

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UV GULLAS COLLEGE OF MEDICINE is one of Top Medical College in Philippines in Cebu city. International students have the oppertunity to study medicine in phillipines at affordable cost and world class University. The college has successful alumni who have achieved well in the fields of law, business, politics, academe, medicine, sports and other endeavors. At University of the Visayas, we prepare students for a global competition.
ReplyDeleteDirect MBBS Admissions Open: 2020-21
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